49ers defensive tackle Alfred Collins is out for the season after tearing his patellar tendon, raising questions about how San Francisco's defensive line will adapt in 2026. Despite Collins' rocky preseason and early struggles, offseason acquisition Osa Odighizuwa looks primed for a breakout year, and young talents like CJ West, James Thompson, and Grayson Halton offer plenty of upside alongside Nick Bosa and under the guidance of coach Chris Kocurek. With the season opener set against the Los Angeles Rams in Melbourne, Christian McCaffrey and Deebo Samuel could be in line for explosive performances against a fierce Rams defensive front. Quick releases, dump-offs, and jet sweeps may be crucial for Brock Purdy as he looks to keep pressure at bay while getting the ball into the hands of his playmakers. Will the early workload for CMC and Deebo set the tone for a dominant 49ers attack?