Brock Purdy faces his biggest test yet as the San Francisco 49ers clash with the Seattle Seahawks' elite defense, led by coordinator Mike Macdonald. With Purdy's previous struggles against Macdonald’s schemes—highlighted by a passer rating drop to 75.8 and a four-interception game versus Baltimore—questions swirl: Can Purdy finally crack Seattle’s code, or will the Seahawks maintain their dominance? Key stats, low-scoring games, and the pivotal battle for playoff seeding all take center stage. Christian McCaffrey is expected to play a crucial role with an increased workload both between the tackles and in the passing game, while Purdy’s underrated rushing ability could be the X-factor. Will the 49ers offense break through, or does Seattle keep their grip on this rivalry? Turnovers, third-down conversions, and late-game quarterback runs may well determine who comes out on top in this NFC West showdown.