Can Running Back De'Von Achane ignite the Miami Dolphins offense against a tested San Francisco 49ers defense? Achane’s speed and versatility pose one of the biggest threats, especially after a breakout 2025 season with 1,350 rushing yards and 8 touchdowns. Miami’s hopes of keeping pace hinge on maximizing his touches and exploiting defensive gaps. Will the 49ers be able to contain him or will history repeat after his impressive 2024 stat line against them? Wide receiver Mike Evans looks primed to shred a primarily rookie Dolphins secondary, with first-round cornerback Chris Johnson facing a daunting test after a tough debut. After showcasing standout chemistry with Brock Purdy and notching multiple third-down conversions against the Rams, Evans could dominate one-on-one matchups and exploit defensive miscommunications. Can Miami’s young defense adapt, or will Evans continue his march as a game-changer in Santa Clara?