Osa Odighizuwa arrival could spark a revival of the San Francisco 49ers’ defensive front, reminiscent of their dominant 2019 run to the Super Bowl. After landing the former Dallas Cowboys game wrecker via a third-round pick, Odighizuwa's 52 pressures and 20 quarterback hits last season point to a true force in the trenches alongside Nick Bosa. Can this pairing once again make the Niners’ defensive line a nightmare for quarterbacks and return them to elite status? Enrique Cruz, the 49ers’ fifth-round pick out of Kansas, faces a pivotal preseason audition as the team battles a rash of injuries along the offensive line. With uncertainty at left guard and injuries to key depth players like Austin Pleasants, Dominick Puni, and Brett Toth, the pressure is on Cruz to step up or risk seeing San Francisco seek veteran reinforcements before the regular season kickoff against the Los Angeles Rams in Australia.